期刊
CURRENT OPINION IN INSECT SCIENCE
卷 37, 期 -, 页码 30-38出版社
ELSEVIER
DOI: 10.1016/j.cois.2019.11.007
关键词
-
资金
- National Institutes of Health [GM087341, GM116885]
- University of Iowa, Anatomy and Cell Biology Department
Homeostasis of Drosophila germline stem cells (GSC) depends upon the integration of intrinsic and extrinsic signals. This review highlights emerging data that support nuclear architecture as an intrinsic regulator of GSC maintenance and germ cell differentiation. Here, we focus on the nuclear lamina (NL) and the nucleolus, two compartments that undergo alterations in composition upon germ cell differentiation. Loss of NL or nucleolar components leads to GSC loss, resulting from activation of GSC quality control checkpoint pathways. We suggest that the NL and nucleolus integrate signals needed for the switch between GSC maintenance and germ cell differentiation, and propose regulation of nuclear actin pools as one mechanism that connects these compartments.
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