期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 6, 期 3, 页码 1573-1581出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00042
关键词
Janus nanoparticles; anisotropy; gold-mesoporous silica; codelivery; cancer therapy
资金
- National Natural Science Foundation of China [21874087]
- Hundred Talent Programme of Shanxi Province [2017-Keyl]
- Shanxi Scholarship Council of China [201701D221029]
Codelivery of drugs using multifunctional nanoplatforms with anisotropic properties can produce synergistic effects and improve the antitumor activity of the drugs. In this work, Janus gold-mesoporous silica nanoparticles have been successfully synthesized via the Pickering emulsion method. The obtained Janus nanoparticles were further selectively assembled with thiol-beta-cyclodextrin as a drug delivery vehicle for paclitaxel on gold domains, while the other mesoporous silica side with a mesoporous structure served as a drug delivery vehicle for doxorubicin. These synthesized Janus nanoparticles possess pH and near-infrared (NIR) dual-responsive release properties. Furthermore, the tumor-bearing mice treated with dual-drug-loaded Janus nanoparticles showed obvious tumor inhibition than single-drug-loaded ones. Histological analysis reveals no pathological changes in the vital organs of the mice. The outcome demonstrated that dual-drug-loaded Janus gold-mesoporous silica nanoparticles possessed a high therapeutic efficiency and excellent biocompatibility both in vitro and in vivo and could be used as an effective candidate for cancer therapeutics.
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