期刊
STEM CELL REPORTS
卷 14, 期 2, 页码 338-350出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2020.01.007
关键词
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资金
- W.M. Keck Foundation
- NIH [RO1 CA208405, P30 CA 008748]
- Scientific Research Fund of Hunan Provincial Education Department [16B237]
- Chinese Scholarship Council [183501]
- Wellcome Trust [206194]
- Chan Zuckerberg Initiative DAF [183501]
Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states. Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression. These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance. They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors.
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