期刊
MOLECULAR THERAPY-NUCLEIC ACIDS
卷 19, 期 -, 页码 1368-1378出版社
CELL PRESS
DOI: 10.1016/j.omtn.2020.01.021
关键词
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资金
- National Natural Science Foundation of China [81170496]
- Research Project for Practice Development of National TCM Clinical Research Bases [JDZX2015119]
- Science and Technology Program of Guangdong Province [2016A020226027, 2017B030303001]
- Science and Technology Program of Guangzhou City [201604020140]
- Fundamental Research Funds for the Central Universities [21617461]
- Sanming Project of Medicine in Shenzhen [SZSM201601062]
H19 is a long non-coding RNA which was lowly expressed in chronic myeloid leukemia (CML). Here, we found that the overexpression of H19 significantly inhibited cell viability and colony formation and prolongs survival in CML cell lines and three xenografted mouse models. The H19 target proteins and microRNAs (miRNAs) were identified using a combination of computational prediction and RNA pull-down, including PCBP1, FUS protein, and miR-19a-3p and miR-106b-5p. Targeting PCBP1, FUS protein, miR-19a-3p, and miR-106b-5p significantly inhibits the cell growth and colony formation of CML cell lines. Co-overexpression of H19 and PCBP1, FUS, miR-19a-3p, and miR-106b-5p decreases the inhibitory effect of H19 in CML. These findings might provide a novel molecular insight into CML.
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