期刊
MINERALS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/min10030222
关键词
Acidithiobacillus ferrooxidans; EPS synthesis; biofilm formation; bacteria-ore interactions; quorum sensing
资金
- National Natural Science Foundation of China [31570036, 31370138, 31872621, 31570041]
- Key Scientific and Technological Project of Shandong Province [2019GSF109032]
- Project of Taishan Industry Leading Talent in Shandong province [LJNY201603]
- State Key Laboratory of Microbial Technology Foundation [M2017-01]
Acidithiobacillus ferrooxidans is an acidophilic and chemolithotrophic sulfur- and iron-oxidizing bacterium that has been widely used in the bioleaching process for extracting metals. Extracellular polymeric substances (EPS) are essential for bacteria-ore interactions, and the regulation of EPS synthesis could be an important way of influencing the efficiency of the bioleaching process. Therefore, exploring and utilizing the regulatory pathways of EPS synthesis to improve the bacterial bioleaching capability have posed a challenge in the study and application of bioleaching bacteria. Here, several engineering strains were constructed using genetic manipulation methods. And we revealed the regulatory function of the AfeI/R quorum sensing (QS) system in EPS synthesis and biofilm formation of A. ferrooxidans, and the AfeI/R-mediated EPS synthesis could influence bacteria-substrate interactions and the efficiency of bioleaching. Finally, an AfeI/R-mediated bioleaching model was proposed to illustrate the role of QS system in this process. This study provided new insights into and clues for developing highly efficient bioleaching bacteria and modulating the bioleaching process.
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