期刊
LANCET DIABETES & ENDOCRINOLOGY
卷 7, 期 12, 页码 938-948出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S2213-8587(19)30081-6
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资金
- UK National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care-East Midlands
- NIHR Leicester Biomedical Research Centre
Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2 diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain. Amputations in patients with diabetes have a devastating effect on quality of life and are associated with an alarmingly low life expectancy (on average only 2 years from the amputation). Amputation also places a substantial financial burden on health-care systems and society in general. With the introduction of national diabetes eye screening programmes, the prevalence of blindness in working-age adults is falling. This is not the case, however, with diabetes related amputations. In this Review, we appraise innovative point-of-care devices that enable the early diagnosis of DPN and assess the evidence for early risk factor-based management strategies to reduce the incidence and slow the progression of DPN. We also propose a framework for screening and early multifactorial interventions as the best prospect for preventing or halting DPN and its devastating sequelae.
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