期刊
JOURNAL OF IMMUNOLOGY RESEARCH
卷 2020, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2020/5284728
关键词
-
类别
资金
- National Natural Science Foundation of China [81571833, 91939104]
- National Key Laboratory Open Project of Cardiovascular Disease [2019 kf-02]
- Ministry of Education Key Laboratory Open Project of Myocardial Ischemia [KF201908]
Atherosclerosis is a multifactorial chronic inflammatory arterial disease forming the pathological basis of many cardiovascular diseases such as coronary heart disease, heart failure, and stroke. Numerous studies have implicated inflammation as a key player in the initiation and progression of atherosclerosis. Galectin-3 (Gal-3) is a 30 kDa beta-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. This review focuses on the role of Gal-3 in atherosclerosis and the mechanism involved and several classical Gal-3 agonists and antagonists in the current studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据