期刊
FRONTIERS IN PHARMACOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2020.00082
关键词
morphine addiction; oxidative stress; CPP; thioredoxin-1; geranylgeranylacetone
资金
- National Natural Science Foundation of China [31600837]
- Henan Science and Technology Project [172102310622]
- Henan Science and Technology Innovation Team (Investigation on Plant Resources in Dabie Mountains)
- Study and Utilization of Active Components of Special Plants [2017083]
- Ph.D. Early Development Program [0201427, 16083]
- Nanhu Scholars Program for Young Scholars of XYNU
Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence. Numerous studies have demonstrated significant redox alteration in morphine dependence and addiction. Thioredoxin-1 (Trx-1) play important roles in controlling the cellular redox balance. In recent years, several recent studies have demonstrated that Trx-1 may be a promising novel therapeutic target for morphine addiction. In this article, we firstly review the redox alteration in morphine addiction. We also summarize the expression and the protective roles of Trx-1 in morphine dependence. We further highlight the protection of geranylgeranylacetone (GGA), a noncytotoxic pharmacological inducer of Trx-1, in morphine-induced conditioned place preference. In conclusion, Trx-1 may be very promising for clinical therapy of morphine addiction in the future.
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