期刊
ALLERGOLOGY INTERNATIONAL
卷 69, 期 3, 页码 412-416出版社
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.1016/j.alit.2020.01.005
关键词
IL-13R alpha 2; IL-13; Atopic dermatitis; Scratch; YKL-40
资金
- Ministry of Health, Labour and Welfare, Japan [H30-Shokuhin-Shitei-005]
- Leading Advanced Projects for Medical Innovation, Japan (LEAP)
Atopic dermatitis (AD) is a common eczematous skin disorder characterized by skin inflammation, barrier disruption, chronic pruritus and marked scratching. Th2 cytokines, especially IL-13, play a pathogenic role in AD. IL-13 signals via a heterodimeric receptor composed of IL-4R alpha and IL-13 R alpha 1. A second receptor, IL-13 R alpha 2, binds to IL-13 with high affinity, but it works as a decoy receptor. IL-13 R alpha 2 is overexpressed in the lesional skin of AD. Notably, mechanical scratching, as well as IL-13 itself, also upregulates IL-13 Rat expression. The scratch-induced IL-13 R alpha 2 upregulation may attenuate the IL-13-mediated epidermal barrier dysfunction and dermal fibrosis. Recent studies stress an importance of another IL-13 R alpha 2 ligand, chitinase 3-like 1 or YKL-40 in Th2 differentiation. However, the implications of increased IL-13 R alpha 2 levels remain elusive in AD. In this review, we summarize the recent topics on IL-13 R alpha 2 in atopic skin inflammation. Copyright (C) 2020, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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