期刊
FRONTIERS IN PLANT SCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2020.00050
关键词
Por1; mitochondria; reactive oxygen species; stress; mitochondrial membrane potential; Arabidopsis
资金
- Department of Atomic Energy (DAE), Board of Research in Nuclear Sciences (BRNS), Department of Biotechnology (DBT), Department of Science and Technology (DST-PURSE grant), Delhi University (RD grant), India
Voltage-dependent anion channels (VDACs) are conserved proteins of the mitochondria. We have functionally compared Arabidopsis VDACs using Saccharomyces cerevisiae Delta por1 and M3 yeast system. VDAC (1, 2, and 4) were able to restore Delta por1 growth in elevated temperature, in oxidative and salt stresses, whereas VDAC3 only partially rescued Delta por1 in these conditions. The ectopic expression of VDAC (1, 2, 3, and 4) in mutant yeast recapitulated the mitochondrial membrane potential thus, enabled it to maintain reactive oxygen species homeostasis. Overexpression of these VDACs (AtVDACs) in M3 strain did not display any synergistic or antagonistic activity with the native yeast VDAC1 (ScVDAC1). Collectively, our data suggest that Arabidopsis VDACs are involved in regulating respiration, reactive oxygen species homeostasis, and stress tolerance in yeast.
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