期刊
ELIFE
卷 9, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.50631
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资金
- Swiss National Science Foundation [31003A-152614, 31003A-176206]
- Swiss National Science Foundation NCCR Synapsy [51NF40158776, 51NF40185897]
- EU Seventh Framework Programme [603016]
- Ecole Polytechnique Federale de Lausanne Jebsen Research Program
- Center for Biomedical Imaging
- Swiss National Science Foundation (SNF) [31003A_176206] Funding Source: Swiss National Science Foundation (SNF)
Emerging evidence suggests that hierarchical status provides vulnerability to develop stress-induced depression. Energy metabolic changes in the nucleus accumbens (NAc) were recently related to hierarchical status and vulnerability to develop depression-like behavior. Acetyl-L-carnitine (LAC), a mitochondria-boosting supplement, has shown promising antidepressant-like effects opening therapeutic opportunities for restoring energy balance in depressed patients. We investigated the metabolic impact in the NAc of antidepressant LAC treatment in chronically-stressed mice using H-1-magnetic resonance spectroscopy (H-1-MRS). High rank, but not low rank, mice, as assessed with the tube test, showed behavioral vulnerability to stress, supporting a higher susceptibility of high social rank mice to develop depressive-like behaviors. High rank mice also showed reduced levels of several energy-related metabolites in the NAc that were counteracted by LAC treatment. Therefore, we reveal a metabolic signature in the NAc for antidepressant-like effects of LAC in vulnerable mice characterized by restoration of stress-induced neuroenergetics alterations and lipid function.
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