期刊
CURRENT RHEUMATOLOGY REPORTS
卷 21, 期 12, 页码 -出版社
SPRINGER
DOI: 10.1007/s11926-019-0867-0
关键词
Cardiac complications; Systemic sclerosis; Scleroderma; Diagnosis; Management
类别
资金
- Scleroderma Foundation
- CHEST Foundation
- Chresanthe Staurulakis Memorial Discovery Fund
- NIH/NHLBI [U01HL175125, R01HL114910-06]
- European Respiratory Society Research Fellowship
- Ann Dana Kusch Multidisciplinary Program for Interstitial Lung Disease and Pulmonary Hypertension
- NIH/NIAMS [R01AR073208]
Purpose of the Review Systemic sclerosis (scleroderma) is a complex autoimmune disease that commonly involves the cardiovascular system. Even if often subclinical, cardiac involvement is considered a poor prognostic factor as it is a leading cause of death in scleroderma patients. We review the cardiac manifestations of scleroderma, the diagnostic methods useful in detection, and current advances in therapeutic management. Recent Findings Beside the routine exams for the assessment of cardiac status (including EKG, standard echocardiography, provocative tests) novel techniques such as myocardial strain imaging on echocardiography, cardiac magnetic resonance imaging, invasive hemodynamic assessment, and endomyocardial biopsy have been demonstrated to be useful in understanding the cardiac alterations that typically affect scleroderma patients. Recent application of novel cardiac detection strategies is providing increased insight into the breadth and pathogenesis of cardiac complications of scleroderma. Further studies coupling exercise provocation, invasive and imaging assessment, and mechanistic studies in scleroderma cardiac tissue are needed to develop the optimal approach to early detection of cardiac disease in scleroderma and targeted therapies.
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