期刊
ADVANCED OPTICAL MATERIALS
卷 8, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adom.201901471
关键词
fluorescence imaging; human serum albumin; IR820; photoacoustic imaging; second near-infrared window
资金
- National Natural Science Foundation of China [81771867, 81771868]
- Young Scholars Program of China Medical University [QGZ-2018036]
- Department of Radiology of Stanford University
Recently, much attention has been focused on the development of second near-infrared window (NIR-II, 1000-1700 nm) fluorescence imaging because of its reduced scattering, minimal absorption, and negligible autofluorescence. NIR-II bioimaging allows the visualization of deep anatomical features with an unprecedented degree of clarity. In addition to the construction of a variety of new NIR-II fluorophores, using a fluorescence tail emission greater than 1000 nm for conventional NIR-I dyes represents a promising strategy for developing an NIR-II imaging technique. Herein, the authors report tailoring a supramolecular assembly of human serum albumin (HSA) protein complexed with a sulfonated NIR-I organic dye (IR820) to produce a brilliant 21-fold increase in fluorescence for NIR-II imaging. In vivo NIR-II imaging with IR820-HSA allows noninvasive and dynamic visualization and monitoring of physiological and pathological conditions of the vascular system, lymphatic drainage system, and tumor-bearing mice, as well as image-guided tumor resection with high spatial and temporal resolution. Furthermore, photoacoustic imaging (PAI) of IR820-HSA in mouse tumor models also demonstrate good tumor accumulation. Overall, an IR820-protein complex with high biocompatibility can be easily constructed using a conventional NIR-I dye that provides a new theranostic tool with high clinical translation potential.
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