期刊
TOXINS
卷 11, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/toxins11120730
关键词
aflatoxin; Aspergillus flavus; HOG pathway; Aflste20
资金
- National Natural Science Foundation of China [31600118]
Various signaling pathways in filamentous fungi help cells receive and respond to environmental information. Previous studies have shown that the mitogen-activated protein kinase (MAPK) pathway is phosphorylation-dependent and activated by different kinase proteins. Serine/threonine kinase plays a very important role in the MAPK pathway. In this study, we selected the serine/threonine kinase AflSte20 in Aspergillus flavus for functional study. By constructing Aflste20 knockout mutants and complemented strains, it was proven that the Aflste20 knockout mutant (Delta Aflste20) showed a significant decrease in growth, sporogenesis, sclerotinogenesis, virulence, and infection compared to the WT (wild type) and complemented strain (Delta Aflste20(C)). Further research indicated that Delta Aflste20 has more sensitivity characteristics than WT and Delta Aflste20(C) under various stimuli such as osmotic stress and other types of environmental stresses. Above all, our study showed that the mitogen-activated kinase AflSte20 plays an important role in the growth, conidia production, stress response and sclerotia formation, as well as aflatoxin biosynthesis, in A. flavus.
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