期刊
POLYMERS
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/polym12020330
关键词
4-n-butylresorcinol; graft copolymers; click chemistry; micellar systems; amphiphilic properties; vitamin delivery; cosmetology
资金
- Ministry of Science and Higher Education (MNiSW, Poland) [DI2016 008246]
A novel initiator, bromoester modified 4-n-butylresorcinol (4nBREBr(2)), was prepared and utilized in controlled atom transfer radical polymerization (ATRP) to obtain three series of amphiphilic copolymers. The V-shaped copolymers of methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA), and poly(ethylene glycol) methyl ether methacrylate (MPEGMA), abbreviated to P(HEMA-co-MMA), P(HEMA-co-MPEGMA), and P(MMA-co-MPEGMA), were synthesized. Moreover, P((HEMA-graft-PEG)-co-MMA) graft copolymers were prepared by combining the pre-polymerization modification of HEMA and a click reaction using a grafting onto approach. All copolymers could form micelles with encapsulated active substances (vitamin C (VitC), vitamin E (VitE), arbutin (ARB)), which are used in cosmetology. In vitro studies carried out in a PBS solution (pH 7.4) demonstrates that in most cases the maximum release of active substance was after 1 h. The polymeric systems presenting satisfactory encapsulation characteristics and release profiles are attractive micellar carriers of cosmetic substances, which show a positive effect on the skin condition.
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