期刊
POLYMERS
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/polym12010034
关键词
micro-extrusion; bio-resorbable scaffold manufacturing; porous scaffolds; poly(L-lactide-co-epsilon-caprolactone); soft tissue engineering
Porous scaffolds made of elastomeric materials are of great interest for soft tissue engineering. Poly(L-lactide-co-epsilon-caprolactone) (PLCL) is a bio-resorbable elastomeric copolymer with tailorable properties, which make this material an appropriate candidate to be used as scaffold for vascular, tendon, and nerve healing applications. Here, extrusion was applied to produce porous scaffolds of PLCL, using NaCl particles as a leachable agent. The effects of the particle proportion and size on leaching performance, dimensional stability, mechanical properties, and ageing of the scaffolds were analyzed. The efficiency of the particle leaching and scaffold swelling when wet were observed to be dependent on the porogenerator proportion, while the secant moduli and ultimate tensile strengths were dependent on the pore size. Porosity, swelling, and mechanical properties of the extruded scaffolds were tailorable, varying with the proportion and size of porogenerator particles and showed similar values to human soft tissues like nerves and veins (E = 7-15 MPa, sigma(u) = 7 MPa). Up to 300-mm length micro-porous PLCL tube with 400-mu m thickness wall was extruded, proving extrusion as a high-throughput manufacturing process to produce tubular elastomeric bio-resorbable porous scaffolds of unrestricted length with tunable mechanical properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据