期刊
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
卷 16, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/ijerph16244896
关键词
animal husbandry; antimicrobials; antibiotic resistance genes; pathogen; high-throughput sequencing; metagenomic analysis
资金
- National Water Pollution Control and Treatment Science and Technology Major Project in China [2017ZX07401002]
- Beijing Natural Science Foundation [6192029]
- Central Public-interest Scientific Institution Basal Research Fund [BSRF201903]
The extensive use of antimicrobials in animal farms poses serious safety hazards to both the environment and public health, and this trend is likely to continue. Antimicrobial resistance genes (ARGs) are a class of emerging pollutants that are difficult to remove once introduced. Understanding the environmental transfer of antimicrobial-resistant bacteria (ARB) and ARGs is pivotal for creating control measures. In this review, we summarize the research progress on the spread and detection of ARB and ARG pollution related to animal husbandry. Molecular methods such as high-throughput sequencing have greatly enriched the information about ARB communities. However, it remains challenging to delineate mechanisms regarding ARG induction, transmission, and tempo-spatial changes in the whole process, from animal husbandry to multiple ecosystems. As a result, future research should be more focused on the mechanisms of ARG induction, transmission, and control. We also expect that future research will rely more heavily on metagenomic -analysis, metatranscriptomic sequencing, and multi-omics technologies
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