期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2020.00052
关键词
cysteine; fumarate; loss-of-function; mitochondrial stress; posttranslational modification (PTM); 2-(S-succino)cysteine (2SC); thiol groups
资金
- Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III (FIS) [PI13/00584, PI14/00328]
- Spanish Ministry of Science, Innovation, and Universities (Ministerio de Ciencia, Innovacion y Universidades) [RTI2018-099200-B-I00]
- Generalitat of Catalonia, Agency for Management of University and Research Grants [2017SGR696]
- Department of Health [SLT002/16/00250]
- FEDER funds from the European Union (A way to build Europe'')
- University of Lleida Predoctoral Fellowship
- Generalitat of Catalonia Predoctoral Fellowship
Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic control and strictly regulated. Nevertheless, physiologically uncontrolled and deleterious reactions take place. It has been proposed that these reactions constitute the basic molecular mechanisms that underlie the maintenance or loss-of-function of neurons and, by extension, cerebral functions during brain aging. In this review article, we focus attention on the role of the nonenzymatic and irreversible adduction of fumarate to the protein thiols, which leads to the formation of S-(2-succino)cysteine (2SC; protein succination) in the human brain. In particular, we first offer a brief approach to the succination reaction, features related to the specificity of protein succination, methods for their detection and quantification, the bases for considering 2SC as a biomarker of mitochondrial stress, the succinated proteome, the cross-regional differences in 2SC content, and changes during brain aging, as well as the potential regulatory significance of fumarate and 2SC. We propose that 2SC defines cross-regional differences of metabolic mitochondrial stress in the human brain and that mitochondrial stress is sustained throughout the healthy adult lifespan in order to preserve neuronal function and survival.
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