期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2020.00011
关键词
Alzheimer's disease; human tau; murine tau; neurodegeneration; tauopathies
资金
- Spanish Ministry of Economy and Competitiveness (Ministerio de Economia, Industria y Competitividad, Gobierno de Espana) [BFU2016-77885-P]
- Structural Funds of the European Union from the Comunidad de Madrid [S2017/BMD-3700]
- Centro de Investigacion Biomedica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII)
- Fundacion R. Areces
- Fundacion La Caixa
Human tauopathies, such as Alzheimer's disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R isoforms are not present in adult mice. In contrast, the adult human brain contains Tau 3R and also Tau 4R isoforms. In addition, the N-terminal sequence of Tau protein in mice and humans differs, a Tau peptide (residues 17-28) being present in the latter but absent in the former. Here we review the main published data on this N-terminal sequence that suggests that human and mouse Tau proteins interact with different endogenous proteins and also show distinct secretion patterns.
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