期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 14, 期 3, 页码 147-154出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17474124.2020.1725472
关键词
Celiac disease; diagnosis; serology; potential celiac disease; seronegative celiac disease
资金
- Dr. Schar
Introduction: This article provides a comprehensive overview of the development and application of serological tests used routinely in clinical practice for the diagnosis and management of adult celiac disease. Areas covered: We summarize existing scientific literature related to anti-endomyseal, anti-tissue transglutaminase, and anti-deamidated gliadin peptide antibodies and detail the current and potential future applications of these tests in celiac disease. Expert commentary: Current serological tests in celiac disease have some of the best performance characteristics among disease-specific tests. However, in adult celiac disease, current diagnostic algorithms still rely on duodenal biopsies to confirm the diagnosis. A 'biopsy avoidance strategy' has been implemented in pediatric celiac disease. Future high-quality studies will help inform on whether this approach can be implemented into adult gastroenterology services. It is envisaged that the next 5 years will see an increasing reliance on serology in the diagnosis of adult celiac disease.
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