期刊
CELL REPORTS
卷 30, 期 9, 页码 3051-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2020.02.030
关键词
-
类别
资金
- Texas Institute of Brain Injury and Repair
- UTSW Peter O'Donnell, Jr. Brain Institute
- UT Southwestern Neuroscience Department
- NIH/NIMH [T32-MH076690]
- Simons Foundation [SFARI 573689, 401220]
- James S. McDonnell Foundation 21st Century Science Initiative in Understanding Human Cognition [220020467]
- NIH [DC014702, DC016340, MH102603]
- Chan Zuckerberg Initiative
- Silicon Valley Community Foundation [HCA-A-1704-01747]
The striatum is a critical forebrain structure integrating cognitive, sensory, and motor information from diverse brain regions into meaningful behavioral output. However, the transcriptional mechanisms underlying striatel development at single-cell resolution remain unknown. Using single-cell RNA sequencing (RNA-seq), we examine the cellular diversity of the early postnatal striatum and show that Foxp1, a transcription factor strongly linked to autism and intellectual disability, regulates the cellular composition, neurochemical architecture, and connectivity of the striatum in a cell-type-dependent fashion. We also identify Foxp1-regulated target genes within distinct cell types and connect these molecular changes to functional and behavioral deficits relevant to phenotypes described in patients with FOXP1 loss-of-function mutations. Using this approach, we could also examine the non-cell-autonomous effects produced by disrupting one cell type and the molecular compensation that occurs in other populations. These data reveal the cell-type-specific transcriptional mechanisms regulated by Foxp1 that underlie distinct features of striatal circuitry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据