期刊
CELL REPORTS
卷 29, 期 13, 页码 4482-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2019.11.098
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资金
- Shared Instrumentation Grant (SIG) Program [S10 RR027366, S10 OD018499]
- NIH [S10 OD016262, HHSN272200900042C, HHSN27220140045C]
- National Institute of Allergy and Infectious Diseases [U19 AI118626, P01 AI106695]
- Brazilian National Council for Scientific and Technological Development [CNPq 232745/2014-5]
- Departamento Administrativo de Ciencia, Tecnologia e Innovacion (COLCIENCIAS)
- Pontificia Universidad Javeriana (Convocatoria 727 Doctorados Nacionales)
- American Association of Immunologists Intersect Fellowship Program for Computational Scientists and Immunologists
Dengue virus (DENV) can cause diseases ranging from dengue fever (DF) to more severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Whether antiviral T cells contribute to the protection against or pathogenesis of severe disease is not well defined. Here, we identified antigen-specific IL-10(+)IFN-gamma(+) double-positive (DP) CD4 T cells during acute DENV infection. While the transcriptomic signatures of DP cells partially overlapped with those of cytotoxic and type 1 regulatory CD4 T cells, the majority of them were non-cytotoxic/Tr1 and included IL21, IL22, CD109, and CCR1. Although we observed a higher frequency of DP cells in DHF, the transcriptomic profile of DP cells was similar in DF and DHF, suggesting that DHF is not associated with the altered phenotypic or functional attributes of DP cells. Overall, this study revealed a DENV-specific DP cell subset in patients with acute dengue disease and argues against altered DP cells as a determinant of DHF.
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