期刊
CELL REPORTS
卷 29, 期 13, 页码 4223-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2019.11.101
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资金
- European Research Council (ERC) [725061]
- Spanish Ministry of Science, Innovation, and Universities [AGL2017-85494-C2-1-R]
- Comunidad de Madrid [2016-T1/BIO-1672]
- European Research Council (ERC) [725061] Funding Source: European Research Council (ERC)
Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD(+)IgM(-) plasmablasts constitute a major lymphocyte population in some mucosal surfaces, including the gut mucosa. Remarkably, secreted IgD binds to gut commensal bacteria, which in turn stimulate IgD gene transcription in gut B cells. Accordingly, secreted IgD from gut as well as gill mucosae, but not the spleen, show a V(D)J gene configuration consistent with microbiota-driven clonal expansion and diversification, including mild somatic hypermutation. By showing that secreted IgD establishes a mutualistic relationship with commensals, our findings suggest that secreted IgD may play an evolutionary conserved role in mucosal homeostasis.
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