期刊
CELL REPORTS
卷 30, 期 2, 页码 320-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2019.12.019
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资金
- European Research Council (ERC) under the European Union [695596]
- SNSF [310030_189153, CRSII3_160702]
- Claraz Foundation
- Institute of Genetics and Genomics of Geneva (iGE3)
- European Research Council (ERC) [695596] Funding Source: European Research Council (ERC)
- Swiss National Science Foundation (SNF) [310030_189153, CRSII3_160702] Funding Source: Swiss National Science Foundation (SNF)
In rodents, the decrease of felid aversion induced by Toxoplasma gondii, a phenomenon termed fatal attraction, is interpreted as an adaptive manipulation by the neurotropic protozoan parasite. With the aim of understanding how the parasite induces such specific behavioral modifications, we performed a multiparametric analysis of T. gondii-induced changes on host behavior, physiology, and brain transcriptome as well as parasite cyst load and distribution. Using a set of complementary behavioral tests, we provide strong evidence that T. gondii lowers general anxiety in infected mice, increases explorative behaviors, and surprisingly alters predator aversion without selectivity toward felids. Furthermore, we show a positive correlation between the severity of the behavioral alterations and the cyst load, which indirectly reflects the level of inflammation during brain colonization. Taken together, these findings refute the myth of a selective loss of cat fear in T. gondii-infected mice and point toward widespread immune-related alterations of behaviors.
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