期刊
CELL REPORTS
卷 30, 期 8, 页码 2614-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2020.01.102
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资金
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- Natural Science Foundation of China [31471026, 31872762]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- ZJLab
Synapses are fundamental to the normal function of the nervous system. Glia play a pivotal role in regulating synaptic formation. However, how presynaptic neurons assemble synaptic structure in response to the glial signals remains largely unexplored. To address this question, we use cima-1 mutant C. elegans as an in vivo model, in which the astrocyte-like VCSC glial processes ectopically reach an asynaptic neurite region and promote presynaptic formation there. Through an RNAi screen, we find that the Rho GTPase CDC-42 and IQGAP PES-7 are required in presynaptic neurons for VCSC gliainduced presynaptic formation. In addition, we find that cdc-42 and pes-7 are also required for normal synaptogenesis during postembryonic developmental stages. PES-7 activated by CDC-42 promotes presynaptic formation, most likely through regulating F-actin assembly. Given the evolutionary conservation of CDC-42 and IQGAPs, we speculate that our findings in C. elegans apply to vertebrates.
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