期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201901186
关键词
drug delivery; inflammation; intervertebral disk degeneration; rapamycin; ROS response
资金
- Soochow University
- Program for Jiangsu Specially-Appointed Professors
- Collaborative Innovation Center of Suzhou Nano Science Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- 111 Project
- National Natural Science Foundation of China [81873995, 31900988, 81171712]
- Social development program of Jiangsu province [BE2019662]
- Gusu medical talents program of Suzhou [20015]
- Health commission of Jiangsu province [H2017066]
- Natural Science Foundation of Jiangsu Province [BK20151213, SBK2019040088]
- Jiangsu Province Six Talent Peaks Project [SWYY-110]
- Key laboratory of spinal cord injury repair of Suzhou [SZS201807]
- Suzhou Young Science and Technology Project [KJXW2018012]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18_2532]
The chronic inflammatory microenvironment is characterized by the elevated level of reactive oxygen species (ROS). Here, it is hypothesized that developing an ROS-scavenging scaffold loaded with rapamycin (Rapa@Gel) may offer a new strategy for modulating the local inflammatory microenvironment to improve intervertebral disk tissue regeneration. The therapeutic scaffold consisting of ROS-degradable hydrogel can be injected into the injured degeneration site of intervertebral disk (IVD) and can release therapeutics in a programmed manner. The ROS scavenged by scaffold reduces the inflammatory responses. It is found that when rats are treated with Rapa@Gel, this results in an increase in the percentage of M2-like macrophages and a decrease in M1-like macrophages in the inflammatory environment, respectively. Regeneration of IVD is achieved by Rapa@Gel local treatment, due to the increased M2 macrophages and reduced inflammation. This strategy may be extended to the treatment of many other inflammatory diseases.
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