期刊
VIRULENCE
卷 11, 期 1, 页码 88-103出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2019.1708053
关键词
(5-10); Malaria; Plasmodium falciparum; monocytes; dendritic cells; gamma-delta T cells; NK cells
资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [AI110852]
Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which complicates vaccine development. Progress has been made in defining the innate signaling pathways activated by parasite components, including DNA, RNA, hemozoin, and phospholipids, which initiate the immune response and will be the focus of this review. The challenge that remains within the field is to understand the role of these early responses in the development of protective adaptive responses that clear iRBC and block merozoite invasion so that optimal vaccines and therapeutics may be produced.
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