期刊
SCIENTIFIC REPORTS
卷 10, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-020-60092-5
关键词
-
资金
- Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development [ZIAHD000266]
- Center for Neuroregenerative Medicine (CNRM) under the Henry Jackson Foundation (HJF)
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [ZIAHD008971] Funding Source: NIH RePORTER
Multidimensional correlation magnetic resonance imaging (MRI) is an emerging imaging modality that is capable of disentangling highly heterogeneous and opaque systems according to chemical and physical interactions of water within them. Using this approach, the conventional three dimensional MR scalar images are replaced with spatially resolved multidimensional spectra. The ensuing abundance in microstructural and chemical information is a blessing that incorporates a real challenge: how does one distill and refine it into images while retaining its significant components? In this paper we introduce a general framework that preserves the spectral information from spatially resolved multidimensional data. Equal weight is given to significant spectral components at the single voxel level, resulting in a summarized image spectrum. This spectrum is then used to define spectral regions of interest that are utilized to reconstruct images of sub-voxel components. Using numerical simulations we first show that, contrary to the conventional approach, the proposed framework preserves spectral resolution, and in turn, sensitivity and specificity of the reconstructed images. The retained spectral resolution allows, for the first time, to observe an array of distinct T-1-T-2-< D > components images of the human brain. The robustly generated images of sub-voxel components overcome the limited spatial resolution of MRI, thus advancing multidimensional correlation MRI to fulfilling its full potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据