期刊
NUTRIENTS
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu12010065
关键词
aging; muscle; amino acids; metabolism; systemic inflammation; profiling; biomarkers; multi-marker; physical performance; gut microbiota
资金
- Innovative Medicines Initiative-Joint Undertaking [IMI-JU] [115621]
- Universita Cattolica del Sacro Cuore [D3.2 2013, D3.2 2015]
- nonprofit research foundation Centro Studi Achille e Linda Lorenzon
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Italian Ministry of Education, Universities and Research
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
Physical frailty and sarcopenia (PF&S) share multisystem derangements, including variations in circulating amino acids and chronic low-grade inflammation. Gut microbiota balances inflammatory responses in several conditions and according to nutritional status. Therefore, an altered gut-muscle crosstalk has been hypothesized in PF&S. We analyzed the gut microbial taxa, systemic inflammation, and metabolic characteristics of older adults with and without PF&S. An innovative multi-marker analytical approach was applied to explore the classification performance of potential biomarkers for PF&S. Thirty-five community dwellers aged 70+, 18 with PF&S, and 17 nonPF&S controls were enrolled. Sequential and Orthogonalized Covariance Selection (SO-CovSel), a multi-platform regression method developed to handle highly correlated variables, was applied. The SO-CovSel model with the best prediction ability using the smallest number of variables was built using seven mediators. The model correctly classified 91.7% participants with PF&S and 87.5% nonPF&S controls. Compared with the latter group, PF&S participants showed higher serum concentrations of aspartic acid, lower circulating levels of concentrations of threonine and macrophage inflammatory protein 1 alpha, increased abundance of Oscillospira and Ruminococcus microbial taxa, and decreased abundance of Barnesiellaceae and Christensenellaceae. Future investigations are warranted to determine whether these biomediators are involved in PF&S pathophysiology and may, therefore, provide new targets for interventions.
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