期刊
NUTRIENTS
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nu12020295
关键词
beans; domestic processing; polyphenols; bioaccessibility; starch digestion; in vitro digestion; anti-inflammatory effect; IL1 beta; iNOS
资金
- National Council on Science and Technology of Mexico [359219]
The consumption of beans has been associated with chronic disease prevention which may be attributed to the polyphenols present in the seed coat and endosperm. However, their bioaccessibility is likely to be limited by interactions with bean matrix components, including starch, protein and fibre. The aim of this project was to evaluate the effect of domestic processing and enzymatic digestion on the bioaccessibility of polyphenols from Borlotti beans (Phaseolus vulgaris) and to test their anti-inflammatory properties in a macrophage cell model. In vitro digestion of cooked beans released twenty times more polyphenols (40.4 +/- 2.5mg gallic acid equivalents (GAE)/g) than domestic processing (2.22 +/- 0.1mg GAE/g), with starch digestion contributing to the highest release (30.9 +/- 0.75mg GAE/g). Fluorescencemicroscopy visualization of isolated bean starch suggests that polyphenols are embedded within the granule structure. LC-MS analysis showed that cooked Borlotti bean contain flavonoids, flavones and hydroxycinnamic acids, and cooked bean extracts exerted moderate anti-inflammatory effects by decreasing mRNA levels of IL1 beta and iNOS by 25% and 40%, respectively. In conclusion, the bioaccessibility of bean polyphenols is strongly enhanced by starch digestion. These polyphenols may contribute to the health benefits associated with bean consumption.
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