期刊
NUTRIENTS
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu12010094
关键词
fructose; glucose; small intestine; liver; brain; gut-brain axis; non-alcoholic fatty liver; insulin resistance; metabolic syndrome; type 2 diabetes mellitus
资金
- Spanish MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD [SAF2016-77871-C2-1-R, SAF2016-77871-C2-2-R]
- EFSD European Research Programme on New Targets for Type 2 Diabetes - MSD
- FUNDACION LA-CAIXA Y FUNDACION CAJA DE BURGOS [CAIXA-UBU001]
The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut-brain axis will be reviewed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据