期刊
NUTRIENTS
卷 12, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nu12030601
关键词
triglyceride-rich lipoprotein; chylomicrons; high density lipoprotein; low density lipoprotein; virgin olive oil
资金
- Instituto de Salud Carlos III [FIS 16-00139, FIS 19-00136, FIS 15-00047, FIS P18/00020, Marato TV3 201512.31]
- FEDER Una manera de hacer Europa [FIS 16-00139, FIS 19-00136, FIS 15-00047, FIS P18/00020, Marato TV3 201512.31]
- Sara Borrell contract [CD17/00233]
The atherogenicity of low-density lipoprotein (LDL) and triglyceride-rich lipoproteins (TRLs) may be more significant than LDL cholesterol levels. Clinical trials which have led to increased high-density lipoprotein (HDL) cholesterol have not always seen reductions in cardiovascular disease (CVD). Furthermore, genetic variants predisposing individuals to high HDL cholesterol are not associated with a lower risk of suffering a coronary event, and therefore HDL functionality is considered to be the most relevant aspect. Virgin olive oil (VOO) is thought to play a protective role against CVD. This review describes the effects of VOO and phenol-enriched VOOs on lipoprotein atherogenicity and HDL atheroprotective properties. The studies have demonstrated a decrease in LDL atherogenicity and an increase in the HDL-mediated macrophage cholesterol efflux capacity, HDL antioxidant activity, and HDL anti-inflammatory characteristics after various VOO interventions. Moreover, the expression of cholesterol efflux-related genes was enhanced after exposure to phenol-enriched VOOs in both post-prandial and sustained trials. Improvements in HDL antioxidant properties were also observed after VOO and phenol-enriched VOO interventions. Furthermore, some studies have demonstrated improved characteristics of TRL atherogenicity under postprandial conditions after VOO intake. Large-scale, long-term randomized clinical trials, and Mendelian analyses which assess the lipoprotein state and properties, are required to confirm these results.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据