期刊
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
卷 12, 期 12, 页码 1939-1950出版社
IJO PRESS
DOI: 10.18240/ijo.2019.12.17
关键词
diabetes mellitus; diabetic keratopathy; diabetic neuropathy; in vivo confocal microscopy; advanced glycation end products
资金
- National Natural Science Foundation of China [81371054, 81600714]
The incidence of diabetes mellitus (DM) and its complications have increased considerably worldwide. Diabetic keratopathy is the major complication of the cornea characterized by delayed corneal wound healing, decreasing corneal epithelial sensitivity, and recurrent corneal ulcers. There is accumulating evidence that diabetic keratopathy is correlated with the hyperglycemic state. Different corneal components may produce different alterations under hyperglycemia. In addition, diabetic nerve alteration may become a novel biomarker of early-stage DM. Abnormalities of the corneal nerve plexus have been associated with diabetic inflammatory states. There is rapidly growing evidence based on investigations of diabetic corneal nerves through in vivo confocal microscopy. Understanding the molecular pathogenesis caused by hyperglycemia may assist in the identification of novel biomarkers, as well as therapeutic targets for early treatment. This review mainly summarizes recent findings on corneal alteration and pathogenesis in DM.
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