期刊
BIOMEDICAL OPTICS EXPRESS
卷 11, 期 3, 页码 1417-1431出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.378506
关键词
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资金
- Australian Government through the Australian Research Council [DP1096514, DP150100635]
- Australian Research Council - Australian Government [FT180100683]
- NHMRC [1141552]
- Brain Pool Program from the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019H1D3A2A02101784]
Terahertz (THz) imaging and optical coherence tomography (OCT) provide complementary information with similar length scales. In addition to OCT's extensive use in ophthalmology, both methods have shown some promise for other medical applications and non-destructive testing. In this paper, we present an iterative algorithm that combines the information from OCT and THz imaging at two different measurement locations within an object to determine both the depth of the reflecting layers at the two locations and the unknown refractive index of the medium for both the OCT wavelengths and THz frequencies. We validate this algorithm using a silicone test object with embedded layers and show that the depths and refractive index values obtained from the algorithm agreed with the measured values to within 3.3%. We further demonstrate for the first time that OCT and THz images can be co-registered and aligned using unsupervised image registration. Hence we show that a combined OCT/THz system can provide unique information beyond the capability of the separate modalities alone, with possible applications in the medical, industrial and pharmaceutical sectors. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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