期刊
BIOMEDICAL OPTICS EXPRESS
卷 11, 期 1, 页码 240-250出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.380996
关键词
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资金
- European Commission Competitiveness for Innovation Program (BabyLux project) [620996]
- European Union [688303]
In time-domain diffuse optical spectroscopy, the simultaneous acquisition of the timeof-flight distribution (DTOF) of photons traveling in a diffusive medium and of the instrument response function (IRF) is necessary to perform quantitative measurements of optical properties (absorption and reduced scattering coefficients) while taking into account the non-idealities of a real system (e.g. temporal resolution and time delays). The IRF acquisition can be a non-trivial and time-consuming operation that requires directly facing the injection and collection fibers. Since this operation is not always possible, a new IRF measurement scheme is here proposed where the IRF is acquired in reflectance geometry from a corrugate reflective surface. Validation measurements on a set of reference homogenous phantoms have been performed, resulting in an error in the optical properties estimation lower than 10% with respect to the typical IRF configuration. Thus, the proposed method proved to be a reliable approach that after a preliminary calibration can be exploited in a laboratory and clinical set-ups, leading to faster and more accurate measurements and reducing the operator-dependent performance. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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