期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-14858-0
关键词
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资金
- Australian Research Council [DP110101200, DP140101968, CE140100007]
- National Health and Medical Research Council [APP1003906, APP1020839, APP1083152, APP1082144, APP1122220]
- International Neuroinformatics Coordinating Facility (INCF Seed Funding grant scheme)
- European Regional Development Fund under the Operational Program Innovative Economy [POIG.02.03.00-00-003/09]
- National Centre for Research and Development [ERA-NET-NEURON/17/2017]
- National Institute of Mental Health [R01MH062349]
- Office of Naval Research [N00014-17-1-2041]
- Cold Spring Harbor Laboratory
- Mathers Foundation
- Indian Institute of Technology Madras
Understanding the principles of neuronal connectivity requires tools for efficient quantification and visualization of large datasets. The primate cortex is particularly challenging due to its complex mosaic of areas, which in many cases lack clear boundaries. Here, we introduce a resource that allows exploration of results of 143 retrograde tracer injections in the marmoset neocortex. Data obtained in different animals are registered to a common stereotaxic space using an algorithm guided by expert delineation of histological borders, allowing accurate assignment of connections to areas despite interindividual variability. The resource incorporates tools for analyses relative to cytoarchitectural areas, including statistical properties such as the fraction of labeled neurons and the percentage of supragranular neurons. It also provides purely spatial (parcellation-free) data, based on the stereotaxic coordinates of 2 million labeled neurons. This resource helps bridge the gap between high-density cellular connectivity studies in rodents and imaging-based analyses of human brains.
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