期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-14307-y
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资金
- National Key R&D Program of China [2017YFA0701301]
- National Natural Science Foundation of China [21922406, 21775071, 21632008]
- Natural Science Foundation of Jiangsu Province [BK20190055]
- Fundamental Research Funds for the Central Universities [020514380185]
- Excellent Research Program of Nanjing University [ZYJH004]
- CAS Key Laboratory of Receptor Research [SIMM1904YKF-03]
- MEXT (Japan)
Afterglow luminescent probes with high signal-to-background ratio show promise for in vivo imaging; however, such probes that can be selectively delivered into target sites and switch on afterglow luminescence remain limited. We optimize an organic electrochromic material and integrate it into near-infrared (NIR) photosensitizer (silicon 2,3-naphthalocyanine bis( trihexylsilyloxide) and (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]) containing nanoparticles, developing an H2S-activatable NIR afterglow probe (F1(2+)-ANP). F1(2+)-ANP displays a fast reaction rate (1563 +/- 141M(-1) s(-1)) and large afterglow turn-on ratio (similar to 122-fold) toward H2S, enabling high-sensitivity and -specificity measurement of H2S concentration in bloods from healthy persons, hepatic or colorectal cancer patients. We further construct a hepatic-tumor- targeting and H(2)Sactivatable afterglow probe (F1(2+)-ANP-Gal) for noninvasive, real-time imaging of tiny subcutaneous HepG(2) tumors (<3 mm in diameter) and orthotopic liver tumors in mice. Strikingly, F1(2+)-ANP- Gal accurately delineates tumor margins in excised hepatic cancer specimens, which may facilitate intraoperative guidance of hepatic cancer surgery.
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