期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-13585-5
关键词
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资金
- cross-council Lifelong Health and Wellbeing initiative [MR/K026992/1]
- Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6]
- Scottish Funding Council [HR03006]
- Medical Research Council UK
- Wellcome Trust (Wellcome Trust Strategic Award STratifying Resilience and Depression Longitudinally (STRADL)) [104036/Z/15/Z]
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Medical Research Council (MRC)
- University of Edinburgh
- CCACE
- MRC University Unit Programme [MC_UU_00007/10]
- University of Bristol [MC_UU_12013/1, MC_UU_12013/9, MC_UU_00011/1]
- Economics and Social Research Council (ESRC) [ES/N000757/1]
- National Institute for Health Research (NIHR)
- NIHR BioResource
- NIHR [Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust]
- NIHR Blood and Transplant Research Unit in Donor Health and Genomics [NIHR BTRU-2014-10024]
- UK Medical Research Council [MR/L003120/1]
- British Heart Foundation [RG/13/13/30194]
- Age UK (Disconnected Mind Project)
- BBSRC [BB/F019394/1] Funding Source: UKRI
- ESRC [ES/N000757/1] Funding Source: UKRI
- MRC [MC_PC_12028, MC_UU_00007/10, UKDRI-5008, MR/L003120/1] Funding Source: UKRI
- British Heart Foundation [RG/13/13/30194, RG/18/13/33946] Funding Source: researchfish
- Medical Research Council [MR/L003120/1, HDR-9004] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0617-10113] Funding Source: researchfish
Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 participants from UK Biobank, we identify 30 (29 previously unreported) independent-loci associated with income. Using a method to meta-analyze data from genetically-correlated traits, we identify an additional 120 income-associated loci. These loci show clear evidence of functionality, with transcriptional differences identified across multiple cortical tissues, and links to GABAergic and serotonergic neurotransmission. By combining our genome wide association study on income with data from eQTL studies and chromatin interactions, 24 genes are prioritized for follow up, 18 of which were previously associated with intelligence. We identify intelligence as one of the likely causal, partly-heritable phenotypes that might bridge the gap between molecular genetic inheritance and phenotypic consequence in terms of income differences. These results indicate that, in modern era Great Britain, genetic effects contribute towards some of the observed socioeconomic inequalities.
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