期刊
ONCOLOGY LETTERS
卷 19, 期 3, 页码 1649-1656出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.11284
关键词
inflammasome; NLRP1; NLRP3; skin carcinogenesis; UVR
类别
资金
- Medical University of Lodz [503/5-064-01/503-1]
- National Centre of Science [2017/25/N/NZ5/02064, 2017/27/B/NZ5/02011]
Inflammasomes are key innate immune system receptors that detect pathogenic endo- and exogenous stressors like microorganisms or ultraviolet radiation (UVR) which activate the highly proinflammatory cytokines interleukin-1 beta and interleukin-18. Inflammasomes are not only involved in inflammation, but also in carcinogenesis and tumor progression. Due to the dynamic increase in non-melanoma skin cancers (NMSC), it has become necessary to determine how UVR, which plays a key role in NMSC development, can regulate the structure and function of inflammasomes. In the present study, the regulatory mechanisms of NOD-Like Receptor Family Pyrin Domain Containing 1 and 3 inflammasome activation as well as an effective inflammasome-mediated immune response after UVR exposition are discussed. The differences and similarities between these molecular complexes that monitor cellular health, inflammation, and skin carcinogenesis are also highlighted. Despite numerous scientific data, more studies are still required to better understand the biology of inflammasomes in skin cancer development and to explore their therapeutic potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据