期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 11, 期 5, 页码 984-990出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.0c00018
关键词
Thiadiazine; Hsp70; MAL1-271; Huntington's disease; molecular chaperone
资金
- National Institutes of Health [P50 GM067082, R35 GM131732, P30 DK79307]
The scope of the acid-mediated 3-component synthesis of thiadiazines was investigated. A selective functionalization of the six-membered heterocyclic core structure was accomplished by sequential alkylations, saponifications, and coupling reactions. Several new analogs of a dihydropyrimidinone Hsp70 chaperone agonist, MAL1-271, showed promising activity in a cell based model of Huntington's disease.
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