期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 11, 期 3, 页码 249-257出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.9b00453
关键词
Kinetoplastids; leishmaniasis; Chagas disease; malaria; protozoan parasite inhibitors; parasite-hopping
资金
- National Institutes of Health [R01AI082577, R56AI099476, R01AI124046, R21AI127594, R01AI126311]
Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites including Trypanosoma cruzi, Leishmania major, Leishmania donovani, and Plasmodium falciparum. This led to the discovery of several compounds with submicromolar activities and improved physicochemical properties that are early leads toward the development of chemotherapeutic agents against kinetoplastid diseases and malaria.
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