期刊
JOURNAL OF FUNCTIONAL FOODS
卷 66, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.103819
关键词
Soy isoflavones; Daidzein; Equol; Intestinal model; TIM-2; Human faeces; Intestinal microbiota
资金
- Spanish Ministry of Economy and Competitiveness (MINECO) [AGL-2014-57820-R]
- Asturias Principality [IDI/2018/000114]
- MINECO within the FPI Program [BES-2015-072285]
- Centre for Healthy Eating & Food Innovation (HEFI) of Maastricht University, Campus Venlo
- Dutch Province of Limburg
In order to find dietary conditions favouring endogenous equol biosynthesis, a pooled faecal homogenate from equol-producing women was used to inoculate the TIM-2 artificial model of the human proximal colon. The model was fuelled with control diets not supplemented (C) or supplemented (C-ISO) with isoflavones, and two isoflavone-containing diets rich in carbohydrate (CH-ISO) or protein (PR-ISO). Compared to the C-ISO control, the CH-ISO diet doubled the production of equol, while with the PR-ISO diet the production of equol in cultures decreased sharply. The CH-ISO diet was also associated with enhanced butyrate production. The numbers of most bacterial populations analysed did not significantly change along cultures with any of the diets. Surprisingly, counts for a gene involved in equol production (tdr) were reduced in all cultures, reflecting a reduction in the number of equol-producing bacteria. In conclusion, under the TIM-2 culture conditions established, the CH-ISO diet favoured the synthesis of equol.
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