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Myelin Plasticity and Repair: Neuro-Glial Choir Sets the Tuning

期刊

FRONTIERS IN CELLULAR NEUROSCIENCE
卷 14, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2020.00042

关键词

myelin; oligodendrocytes; glia; microglia; astrocyte; myelination; plasticity; remyelination

资金

  1. INSERM
  2. ICM
  3. ARSEP
  4. FRM [SPF20110421435, FDT20170437332]
  5. Prix Bouvet-Labruyere-Fondation de France
  6. ANR JC [ANR-17-CE16-0005-01]
  7. FRC ( Espoir en tete, Rotary Club)

向作者/读者索取更多资源

The plasticity of the central nervous system (CNS) in response to neuronal activity has been suggested as early as 1894 by Cajal (1894). CNS plasticity has first been studied with a focus on neuronal structures. However, in the last decade, myelin plasticity has been unraveled as an adaptive mechanism of importance, in addition to the previously described processes of myelin repair. Indeed, it is now clear that myelin remodeling occurs along with life and adapts to the activity of neuronal networks. Until now, it has been considered as a two-part dialog between the neuron and the oligodendroglial lineage. However, other glial cell types might be at play in myelin plasticity. In the present review, we first summarize the key structural parameters for myelination, we then describe how neuronal activity modulates myelination and finally discuss how other glial cells could participate in myelinic adaptivity.

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