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EUROPEAN JOURNAL OF NEUROSCIENCE (2011)
Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice
Daniela Necchi et al.
EXPERIMENTAL NEUROLOGY (2011)
α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome
Mototada Shichiri et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
Cerebrospinal Fluid Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Combination with Subcortical and Cortical Biomarkers in Vascular Dementia and Alzheimer's Disease
Maria Bjerke et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Lysosomal beta-Galactosidase and beta-Hexosaminidase Activities Correlate with Clinical Stages of Dementia Associated with Alzheimer's Disease and Type 2 Diabetes Mellitus
Roberto Tiribuzi et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Microglia Demonstrate Age-Dependent Interaction with Amyloid-beta Fibrils
Angela Marie Floden et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Four faces of cellular senescence
Francis Rodier et al.
JOURNAL OF CELL BIOLOGY (2011)
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
Francis Rodier et al.
JOURNAL OF CELL SCIENCE (2011)
Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease
Isidre Ferrer et al.
JOURNAL OF NEURAL TRANSMISSION (2011)
STUDY OF TELOMERE LENGTH AND DIFFERENT MARKERS OF OXIDATIVE STRESS IN PATIENTS WITH PARKINSON'S DISEASE
G. Watfa et al.
JOURNAL OF NUTRITION HEALTH & AGING (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Guo-li Ming et al.
NEURON (2011)
Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
Hyun Tae Kang et al.
PLOS ONE (2011)
Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid
Marzia Perluigi et al.
PROTEOMICS CLINICAL APPLICATIONS (2011)
Aneuploidy Drives Genomic Instability in Yeast
Jason M. Sheltzer et al.
SCIENCE (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy
Daniela Valenti et al.
BIOCHEMICAL JOURNAL (2010)
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager et al.
BIOLOGICAL PSYCHIATRY (2010)
Oncogene-induced senescence: the bright and dark side of the response
Vassilis G. Gorgoulis et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Stress-induced senescence in human and rodent astrocytes
Alessandro Bitto et al.
EXPERIMENTAL CELL RESEARCH (2010)
Quantitative assessment of markers for cell senescence
Conor Lawless et al.
EXPERIMENTAL GERONTOLOGY (2010)
Plasma membrane microdomains in aging and disease
Yoshiko Ohno-Iwashita et al.
GERIATRICS & GERONTOLOGY INTERNATIONAL (2010)
Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease
Solveig Horstmann et al.
INTERNATIONAL PSYCHOGERIATRICS (2010)
Telomere length and ApoE polymorphism in mild cognitive impairment, degenerative and vascular dementia
Dina Zekry et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2010)
No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients
Johanna Eerola et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2010)
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Joao F. Passos et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
Serum levels of interleukin-6 are elevated in patients with Parkinson's disease and correlate with physical performance
Paula Scalzo et al.
NEUROSCIENCE LETTERS (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Inflammatory networks during cellular senescence: causes and consequences
Adam Freund et al.
TRENDS IN MOLECULAR MEDICINE (2010)
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
Wolfgang J. Streit et al.
ACTA NEUROPATHOLOGICA (2009)
Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease
J. Nicholas Lukens et al.
ALZHEIMERS & DEMENTIA (2009)
The Glial Nature of Embryonic and Adult Neural Stem Cells
Arnold Kriegstein et al.
Annual Review of Neuroscience (2009)
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
Diane C. Cabelof et al.
BLOOD (2009)
Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines
Christopher J. Henry et al.
BRAIN BEHAVIOR AND IMMUNITY (2009)
Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome
Andrea Contestabile et al.
BRAIN PATHOLOGY (2009)
Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome
A. Contestabile et al.
CELL PROLIFERATION (2009)
Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model
Jason Lockrow et al.
EXPERIMENTAL NEUROLOGY (2009)
Vascular endothelial senescence: from mechanisms to pathophysiology
Jorge D. Erusalimsky
JOURNAL OF APPLIED PHYSIOLOGY (2009)
AgNOR status in Down's syndrome infants and a plausible phenotype formation hypothesis
Halil Demirtas
MICRON (2009)
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier et al.
NATURE CELL BIOLOGY (2009)
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes
Na-Hye Myung et al.
AGE (2008)
Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability
Hussein Mansour et al.
AGING CELL (2008)
The aging brain
Bruce A. Yankner et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)
Senescence, apoptosis or autophagy?
Jose Miguel Vicencio et al.
GERONTOLOGY (2008)
Significant effect of APOE Epsilon 4 Genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down Syndrome
V. P. Prasher et al.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2008)
A percentage analysis of the telomere length in Parkinson's disease patients
Jing Zhi Guan et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2008)
Increased absence of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome
Edmund C. Jenkins et al.
NEUROSCIENCE LETTERS (2008)
Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism
Bogdan Brodacki et al.
NEUROSCIENCE LETTERS (2008)
Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study
Francine Grodstein et al.
PLOS ONE (2008)
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
Asako J Nakamura et al.
Epigenetics & Chromatin (2008)
Telomere length and risk of Parkinson's disease
Hao Wang et al.
MOVEMENT DISORDERS (2008)
Glial cell dysregulation: A new perspective on Alzheimer disease
Rommy Von Bernhardi
NEUROTOXICITY RESEARCH (2007)
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
Joao F. Passos et al.
NUCLEIC ACIDS RESEARCH (2007)
Gene expression profiling in the adult Down syndrome brain
H. E. Lockstone et al.
GENOMICS (2007)
Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
Yongqiang Chen et al.
JOURNAL OF CELL SCIENCE (2007)
Human premature aging, DNA repair and RecQ helicases
Robert M. Brosh et al.
NUCLEIC ACIDS RESEARCH (2007)
A continuous correlation between oxidative stress and telomere shortening in fibroblasts
Torsten Richter et al.
EXPERIMENTAL GERONTOLOGY (2007)
Regulation of cell cycle progression and gene expression by H2A deubiquitination
Heui-Yun Joo et al.
NATURE (2007)
Aging and base excision repair: In need of a comprehensive approach
D. C. Cabelof
DNA REPAIR (2007)
β-amyloid pathology in the entorhinal cortex of rats induces memory deficits:: Implications for Alzheimer's disease
E. Sipos et al.
NEUROSCIENCE (2007)
Oxidative stress and aberrant signaling in aging and cognitive decline
Wulf Droge et al.
AGING CELL (2007)
Astrocytes aged in vitro show a decreased neuroprotective capacity
M. Pertusa et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
Karl Herrup et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Involvement of interferon-γ in microglial-mediated loss of dopaminergic neurons
Matthew P. Mount et al.
JOURNAL OF NEUROSCIENCE (2007)
Evidence that aging and amyloid promote microglial cell senescence
Barry E. Flanary et al.
REJUVENATION RESEARCH (2007)
Microglia derived from aging mice exhibit an altered inflammatory profile
Amanda Sierra et al.
GLIA (2007)
NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis
Jorge Busciglio et al.
CURRENT PHARMACEUTICAL DESIGN (2007)
Alzheimer's disease in Down syndrome: Neurobiology and risk
Warren B. Zigman et al.
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS (2007)
Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with down syndrome and in Ts65Dn mice
Andrea Contestabile et al.
HIPPOCAMPUS (2007)
The molecular basis of the prevention of Alzheimer's disease through healthy nutrition
Megan Steele et al.
EXPERIMENTAL GERONTOLOGY (2007)
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
Yi Tang et al.
MOLECULAR CELL (2006)
The significance of neuroinflammation in understanding Alzheimer's disease
P. Eikelenboom et al.
JOURNAL OF NEURAL TRANSMISSION (2006)
Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
Melissa K. McCoy et al.
JOURNAL OF NEUROSCIENCE (2006)
Neuroanatomy of Down syndrome in vivo:: A model of preclinical Alzheimer's disease
Stefan J. Teipel et al.
BEHAVIOR GENETICS (2006)
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
MG Frank et al.
NEUROBIOLOGY OF AGING (2006)
Senescence-associated β-galactosidase is lysosomal β-galactosidase
BY Lee et al.
AGING CELL (2006)
Cellular senescence in aging primates
U Herbig et al.
SCIENCE (2006)
No association between telomere length and survival among the elderly and oldest old
C Bischoff et al.
EPIDEMIOLOGY (2006)
Microglia in the aging brain
Jessica R. Conde et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)
Chronically increased oxidative stress in fibroblasts from Alzheimer's disease patients causes early senescence and renders resistance to apoptosis by oxidative stress
W Naderi et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2006)
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity
LY Hao et al.
CELL (2005)
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis
Y Takahashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
C Cunningham et al.
JOURNAL OF NEUROSCIENCE (2005)
Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects
M Kimura et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
D Hockemeyer et al.
EMBO JOURNAL (2005)
The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease
Z Nagy
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2005)
Aggregated α-synuclein activates microglia:: a process leading to disease progression in Parkinson's disease
W Zhang et al.
FASEB JOURNAL (2005)
Interleukin-1β can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
JI Park et al.
CYTOKINE (2005)
The microglial activation continuum: from innate to adaptive responses
Terrence Town et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
OA Sedelnikova et al.
NATURE CELL BIOLOGY (2004)
Telomeres and telomerase
SRWL Chan et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2004)
Replicative senescence: a critical review
VJ Cristofalo et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
S Ferrón et al.
DEVELOPMENT (2004)
Minocycline prevents cholinergic loss in a mouse model of Down's syndrome
CL Hunter et al.
ANNALS OF NEUROLOGY (2004)
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
U Herbig et al.
MOLECULAR CELL (2004)
Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes
BE Flanary et al.
GLIA (2004)
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
K Imamura et al.
ACTA NEUROPATHOLOGICA (2003)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
p38 MAP kinase is activated at early stages in Alzheimer's disease brain
AY Sun et al.
EXPERIMENTAL NEUROLOGY (2003)
DNA damage foci at dysfunctional telomeres
H Takai et al.
CURRENT BIOLOGY (2003)
Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis
L Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cerebral pattern of pro- and anti-inflammatory cytokines in dementias
E Tarkowski et al.
BRAIN RESEARCH BULLETIN (2003)
Chronic stress and age-related increases in the proinflammatory cytokine IL-6
JK Kiecolt-Glaser et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Genomic medicine: Alzheimer's disease and Parkinson's disease
RL Nussbaum et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Erosion of the telomeric single-strand overhang at replicative senescence
SA Stewart et al.
NATURE GENETICS (2003)
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
V Serra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Genetic and host factors for dementia in Down's syndrome
N Schupf
BRITISH JOURNAL OF PSYCHIATRY (2002)
Senescence induced by altered telomere state, not telomere loss
J Karlseder et al.
SCIENCE (2002)
Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice
DC Cabelof et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2002)
Protection of mammalian telomeres
T de Lange
ONCOGENE (2002)
Leukocyte lysosomal enzymes in Alzheimer's disease and Down's syndrome
S Kalanj-Bognar et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2002)
Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease
MI Combrinck et al.
NEUROSCIENCE (2002)
Homocysteine metabolism in children with Down syndrome: In vitro modulation
M Pogribna et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Assignment of the mouse Park2(PARKIN), the homologue to a new human Parkinson candidate gene, to the telomeric region of mouse 17A3.2-3.3, by in situ hybridization
AC Tomac et al.
CYTOGENETICS AND CELL GENETICS (2001)
The neuronal endosomal-lysosomal system in Alzheimer's disease
Ralph A. Nixon et al.
JOURNAL OF ALZHEIMERS DISEASE (2001)
Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease
A Leake et al.
NEUROSCIENCE LETTERS (2000)
Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia
JD Luterman et al.
ARCHIVES OF NEUROLOGY (2000)
Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain
Y Yoshiyama et al.
ACTA NEUROPATHOLOGICA (2000)
Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a
HJ Lüth et al.
BRAIN RESEARCH (2000)
Nutrition, oxidative damage, telomere shortening, and cellular senescence: Individual or connected agents of aging?
BJ Jennings et al.
MOLECULAR GENETICS AND METABOLISM (2000)
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
T Von Zglinicki et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
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