期刊
VIRUSES-BASEL
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/v12020244
关键词
coronaviruses; SARS-CoV-2; SARS-CoV; genomic comparison; proteomic comparison; pathogenic mechanism; clinical manifestations
类别
资金
- 2020 New Coronavirus Prevention and Control Emergency Project [201100310300]
- Program for Innovative Talents of Science and Technology in Henan Province [18HASTIT048]
After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as coronavirus disease 2019 (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms.
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