期刊
VIRUSES-BASEL
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v12010083
关键词
feline coronavirus; feline infectious peritonitis; spike protein; serotype; genetic characterization
类别
资金
- Cornell Feline Health Center
- Winn Feline Foundation
- NIH Comparative Medicine Training Program [T32OD011000]
Feline coronavirus (FCoV) is a complex viral agent that causes a variety of clinical manifestations in cats, commonly known as feline infectious peritonitis (FIP). It is recognized that FCoV can occur in two different serotypes. However, differences in the S protein are much more than serological or antigenic variants, resulting in the effective presence of two distinct viruses. Here, we review the distinct differences in the S proteins of these viruses, which are likely to translate into distinct biological outcomes. We introduce a new concept related to the non-taxonomical classification and differentiation among FCoVs by analyzing and comparing the genetic, structural, and functional characteristics of FCoV and the FCoV S protein among the two serotypes and FCoV biotypes. Based on our analysis, we suggest that our understanding of FIP needs to consider whether the presence of these two distinct viruses has implications in clinical settings.
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