相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Dynamic Metabolomics for Engineering Biology: Accelerating Learning Cycles for Bioproduction
Christopher J. Vavricka et al.
TRENDS IN BIOTECHNOLOGY (2020)
From nutritional wealth to autophagy: In vivo metabolic dynamics in the cytosol, mitochondrion and shuttles of IgG producing CHO cells
Lisa Junghans et al.
METABOLIC ENGINEERING (2019)
Dynamic changes of metabolomics and expression of candicidin biosynthesis gene cluster caused by the presence of a pleiotropic regulator AdpA in Streptomyces ZYJ-6
Xiaoyun Liu et al.
BIOPROCESS AND BIOSYSTEMS ENGINEERING (2019)
Omics-based analyses revealed metabolic responses of Clostridium acetobutylicum to lignocellulose-derived inhibitors furfural, formic acid and phenol stress for butanol fermentation
Huanhuan Liu et al.
BIOTECHNOLOGY FOR BIOFUELS (2019)
Comparative Fluxome and Metabolome Analysis of Formate as an Auxiliary Substrate for Penicillin Production in Glucose-Limited Cultivation of Penicillium chrysogenum
Guan Wang et al.
BIOTECHNOLOGY JOURNAL (2019)
Quantitative metabolomics and metabolic flux analysis reveal impact of altered trehalose metabolism on metabolic phenotypes of Penicillium chrysogenum in aerobic glucose-limited chemostats
Guan Wang et al.
BIOCHEMICAL ENGINEERING JOURNAL (2019)
A model-based framework for parallel scale-down fed-batch cultivations in mini-bioreactors for accelerated phenotyping
Emmanuel Anane et al.
BIOTECHNOLOGY AND BIOENGINEERING (2019)
A dynamic model-based preparation of uniformly-13C-labeled internal standards facilitates quantitative metabolomics analysis of Penicillium chrysogenum
Guan Wang et al.
JOURNAL OF BIOTECHNOLOGY (2019)
Combining metabolic flux analysis and adaptive evolution to enhance lipase production in Bacillus subtilis
Kai Yuan et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2019)
Leveraging knowledge engineering and machine learning for microbial bio-manufacturing
Tolutola Oyetunde et al.
BIOTECHNOLOGY ADVANCES (2018)
Amino acids production focusing on fermentation technologies - A review
Martina D'Este et al.
BIOTECHNOLOGY ADVANCES (2018)
Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid production from sugarcane molasses
Jun Feng et al.
BIOTECHNOLOGY FOR BIOFUELS (2018)
Integrated Analysis of the Transcriptome and Metabolome of Corynebacterium glutamicum during Penicillin-Induced Glutamic Acid Production
Takashi Hirasawa et al.
BIOTECHNOLOGY JOURNAL (2018)
Monitoring cellular redox state under hypoxia using a fluorescent sensor based on eel fluorescent protein
Hanyang Hu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2018)
Temperature enhanced succinate production concurrent with increased central metabolism turnover in the cyanobacterium Synechocystis sp PCC 6803
Tomohisa Hasunuma et al.
METABOLIC ENGINEERING (2018)
Understanding the metabolic burden of recombinant antibody production in Saccharomyces cerevisiae using a quantitative metabolomics approach
Jorg C. de Ruijter et al.
YEAST (2018)
Integrated Analysis of the Transcriptome and Metabolome of Corynebacterium glutamicum during Penicillin-Induced Glutamic Acid Production
Takashi Hirasawa et al.
BIOTECHNOLOGY JOURNAL (2018)
Comparative performance of different scale-down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis
Guan Wang et al.
MICROBIAL BIOTECHNOLOGY (2018)
Functional metabolomics approach reveals the reduced biosynthesis of fatty acids and TCA cycle is required for pectinase activity in Bacillus licheniformis
Yi Guan et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2018)
Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition
Hongzhong Lu et al.
SCIENTIFIC REPORTS (2018)
Systematic Analysis of Bottlenecks in a Multibranched and Multilevel Regulated Pathway: The Molecular Fundamentals of L-Methionine Biosynthesis in Escherichia coli
Jian-Feng Huang et al.
ACS SYNTHETIC BIOLOGY (2018)
Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels
Guan Wang et al.
BIOTECHNOLOGY AND BIOENGINEERING (2018)
Metabolomics approach used for understanding temperature-related pectinase activity in Bacillus licheniformis DY2
Yi Guan et al.
FEMS MICROBIOLOGY LETTERS (2018)
Metabolic profile of 1,5-diaminopentane producing Corynebacterium glutamicum under scale-down conditions: Blueprint for robustness to bioreactor inhomogeneities
Michael H. Limberg et al.
BIOTECHNOLOGY AND BIOENGINEERING (2017)
Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine
Pingping Tian et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2017)
Rapid screening of cellular stress responses in recombinant Pichia pastoris strains using metabolite profiling
Gregory D. Tredwell et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2017)
Mass-Based Metabolomic Analysis of Lactobacillus sakei and Its Growth Media at Different Growth Phases
Sang Bong Lee et al.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2017)
Rapid discrimination of strain-dependent fermentation characteristics among Lactobacillus strains by NMR-based metabolomics of fermented vegetable juice
Satoru Tomita et al.
PLOS ONE (2017)
The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion
Matthias Brunner et al.
BIOTECHNOLOGY JOURNAL (2017)
Scale-up/Scale-down of microbial bioprocesses: a modern light on an old issue
Frank Delvigne et al.
MICROBIAL BIOTECHNOLOGY (2017)
Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond
Frank Delvigne et al.
MICROBIAL BIOTECHNOLOGY (2017)
13C-assisted metabolomics analysis reveals the positive correlation between specific erythromycin production rate and intracellular propionyl-CoA pool size in Saccharopolyspora erythraea
Ming Hong et al.
BIOPROCESS AND BIOSYSTEMS ENGINEERING (2017)
Comparative fluxome and metabolome analysis for overproduction of succinate in Escherichia coli
Hilal Taymaz-Nikerel et al.
BIOTECHNOLOGY AND BIOENGINEERING (2016)
Computing the various pathways of penicillin synthesis and their molar yields
Maria T. E. Prausse et al.
BIOTECHNOLOGY AND BIOENGINEERING (2016)
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
Walter W. Chen et al.
CELL (2016)
Biobased organic acids production by metabolically engineered microorganisms
Yun Chen et al.
CURRENT OPINION IN BIOTECHNOLOGY (2016)
Metabolomics-based analysis revealing the alteration of primary carbon metabolism by the genetic manipulation of a hydrogenase HoxH in Synechocystis sp PCC 6803
Hiroko Iijima et al.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2016)
Microbial enzymes: industrial progress in 21st century
Rajendra Singh et al.
3 BIOTECH (2016)
Metabolome analysis of Saccharomyces cerevisiae and optimization of culture medium for S-adenosyl-L-methionine production
Kenshi Hayakawa et al.
AMB EXPRESS (2016)
Microbial enzymes: industrial progress in 21st century
Rajendra Singh et al.
3 BIOTECH (2016)
A quantitative metabolomics study of high sodium response in Clostridium acetobutylicum ATCC 824 acetone-butanol-ethanol (ABE) fermentation
Xinhe Zhao et al.
SCIENTIFIC REPORTS (2016)
A metabolomics-based strategy for identification of gene targets for phenotype improvement and its application to 1-butanol tolerance in Saccharomyces cerevisiae
Shao Thing Teoh et al.
BIOTECHNOLOGY FOR BIOFUELS (2015)
Compartment-specific metabolomics for CHO reveals that ATP pools in mitochondria are much lower than in cytosol
Jens-Christoph Matuszczyk et al.
BIOTECHNOLOGY JOURNAL (2015)
Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus
Baohua Wang et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2015)
Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008
Gao-Yi Tan et al.
METABOLIC ENGINEERING (2015)
Compartment-specific metabolomics for CHO reveals that ATP pools in mitochondria are much lower than in cytosol
Jens-Christoph Matuszczyk et al.
BIOTECHNOLOGY JOURNAL (2015)
Overview of citric acid production from Aspergillus niger
Pau Loke Show et al.
FRONTIERS IN LIFE SCIENCE (2015)
Mass-spectrometry-based microbial metabolomics: recent developments and applications
Peng Gao et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)
Amino Acid and Glucose Metabolism in Fed-Batch CHO Cell Culture Affects Antibody Production and Glycosylation
Yuzhou Fan et al.
BIOTECHNOLOGY AND BIOENGINEERING (2015)
Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses
Guan Wang et al.
ENGINEERING IN LIFE SCIENCES (2015)
The therapeutic monoclonal antibody market
Dawn M. Ecker et al.
MABS (2015)
Comparative metabolomics analysis of the key metabolic nodes in propionic acid synthesis in Propionibacterium acidipropionici
Ningzi Guan et al.
METABOLOMICS (2015)
Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics
Nicholas D. Gold et al.
MICROBIAL CELL FACTORIES (2015)
Prelude to rational scale-up of penicillin production: a scale-down study
Guan Wang et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)
Assessment of robustness against dissolved oxygen/substrate oscillations for C-glutamicum DM1933 in two-compartment bioreactor
Friedrich Kass et al.
BIOPROCESS AND BIOSYSTEMS ENGINEERING (2014)
Comparative Metabolic Profiling Revealed Limitations in Xylose-Fermenting Yeast During Co-Fermentation of Glucose and Xylose in the Presence of Inhibitors
Xin Wang et al.
BIOTECHNOLOGY AND BIOENGINEERING (2014)
Constitutive homologous expression of phosphoglucomutase and transaldolase increases the metabolic flux of Fusarium oxysporum
George E. Anasontzis et al.
MICROBIAL CELL FACTORIES (2014)
Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process
Zhibiao Fu et al.
MICROBIAL CELL FACTORIES (2014)
Metabolic flux analysis of recombinant Pichia pastoris growing on different glycerol/methanol mixtures by iterative fitting of NMR-derived 13C-labelling data from proteinogenic amino acids
Joel Jorda et al.
NEW BIOTECHNOLOGY (2014)
Quantitative Metabolomics and Instationary 13C-Metabolic Flux Analysis Reveals Impact of Recombinant Protein Production on Trehalose and Energy Metabolism in Pichia pastoris
Joel Jorda et al.
METABOLITES (2014)
Rational medium optimization based on comparative metabolic profiling analysis to improve fumaric acid production
Guanyi Wang et al.
BIORESOURCE TECHNOLOGY (2013)
Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation
Gulay Ozcengiz et al.
BIOTECHNOLOGY ADVANCES (2013)
Systems-Wide Analysis and Engineering of Metabolic Pathway Fluxes in Bio-Succinate Producing Basfia Succiniciproducens
Judith Becker et al.
BIOTECHNOLOGY AND BIOENGINEERING (2013)
Investigating xylose metabolism in recombinant Saccharomyces cerevisiae via 13C metabolic flux analysis
Xueyang Feng et al.
MICROBIAL CELL FACTORIES (2013)
Single-Cell Metabolomics: Analytical and Biological Perspectives
R. Zenobi
SCIENCE (2013)
Comparative Metabolomic Study of Penicillium chrysogenum During Pilot and Industrial Penicillin Fermentations
Ming-Zhu Ding et al.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2012)
Comparative analysis of intracellular metabolites of Cephalosporium acremonium in pilot and industrial fermentation processes
Yang Yang et al.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2012)
Debottlenecking recombinant protein production in Bacillus megaterium under large-scale conditions-targeted precursor feeding designed from metabolomics
Claudia Korneli et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Scale-up of microbial processes: Impacts, tools and open questions
R. Takors
JOURNAL OF BIOTECHNOLOGY (2012)
Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose: methanol mixtures
Joel Jorda et al.
MICROBIAL CELL FACTORIES (2012)
Quantitative metabolomics analysis of amino acid metabolism in recombinant Pichia pastoris under different oxygen availability conditions
Marc Carnicer et al.
MICROBIAL CELL FACTORIES (2012)
Comparison of the secondary metabolites in Penicillium chrysogenum between pilot and industrial penicillin G fermentations
Ying-Xiu Cao et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)
Metabolic pathway engineering based on metabolomics confers acetic and formic acid tolerance to a recombinant xylose-fermenting strain of Saccharomyces cerevisiae
Tomohisa Hasunuma et al.
MICROBIAL CELL FACTORIES (2011)
Metabolomics as a tool for target identification in strain improvement: the influence of phenotype definition
Machtelt Braaksma et al.
MICROBIOLOGY-SGM (2011)
Fast sampling for quantitative microbial metabolomics
Walter M. van Gulik
CURRENT OPINION IN BIOTECHNOLOGY (2010)
Analysing overexpression of l-valine biosynthesis genes in pyruvate-dehydrogenase-deficient Corynebacterium glutamicum
Tobias Bartek et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2010)
The antibiotics market
Bashar Hamad
NATURE REVIEWS DRUG DISCOVERY (2010)
Hypoxic fed-batch cultivation of Pichia pastoris increases specific and volumetric productivity of recombinant proteins
Kristin Baumann et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
An adpA homologue in Streptomyces avermitilis is involved in regulation of morphogenesis and melanogenesis
Zhao JinLei et al.
CHINESE SCIENCE BULLETIN (2007)
Mass spectrometry-based metabolomics
Katja Dettmer et al.
MASS SPECTROMETRY REVIEWS (2007)
Living with heterogeneities in bioreactors
Alvaro R. Lara et al.
MOLECULAR BIOTECHNOLOGY (2006)
Characterization of S-adenosylmethionine synthetase from Streptomyces avermitilis NRRL8165 and its effect on antibiotic production
Gee-Sun Yoon et al.
ENZYME AND MICROBIAL TECHNOLOGY (2006)
Metabolomics reviewed: A new Omics platform technology for systems biology and implications for natural products research
S Rochfort
JOURNAL OF NATURAL PRODUCTS (2005)
MIRACLE:: mass isotopomer ratio analysis of U-13C-labeled extracts.: A new method for accurate quantification of changes in concentrations of intracellular metabolites
MR Mashego et al.
BIOTECHNOLOGY AND BIOENGINEERING (2004)
Widespread activation of antibiotic blosynthesis by S-adenosylmethionine in streptomycetes
JH Huh et al.
FEMS MICROBIOLOGY LETTERS (2004)
Advances in the production of human therapeutic proteins in yeasts and filamentous fungi
TU Gerngross
NATURE BIOTECHNOLOGY (2004)
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production
S Murli et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2003)
分享论文
