期刊
VIROLOGY
卷 541, 期 -, 页码 150-159出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2019.12.009
关键词
HEV infection; Male genital tract; Sperm quality; Testicular damage
类别
资金
- National Natural Science Foundation of China [81660338, 81960370]
- Natural Science Foundation of Yunnan Province [2017FA036, 2018FB132]
- Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2019-I2M-1-004]
- PUMC Youth Fund [3332019008]
Hepatitis E virus (HEV) is the main pathogen of hepatitis E infections with multiple extrahepatic replication sites. The presence of HEV RNA in the semen of infertile males suggests HEV replicates in the male genital tract. However, the mechanism is largely remained elusive. A BALB/c-based animal model was used to evaluate the effects of HEV infection on the testicular damage. HEV RNA was detected in feces, blood and livers from 7 to 28 days post-inoculation (dpi), while was positive in male genital tract from 7 to 70 dpi. Positive signals of HEV antigens were observed in testes, epididymides and seminal vesicles (SVs). Impaired sperm quality, destroyed the blood-testis barrier (BTB) and drastically decreased spermatogonia suggested that HEV infection causes testicular damage. Antiviral immune response was barely found in the testes. Results demonstrated that HEV replicates in male genital tract, causes testicular damage, and consequently results in flawed fertility.
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