期刊
CANCER LETTERS
卷 370, 期 2, 页码 268-274出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.11.003
关键词
Cancer stem cell; Self-renewal; Stemness; Epigenetic regulator; Microenvironment; Therapeutic target
类别
资金
- National Natural Science Foundation of China (NSFC) [81372864, 81172554]
Osteosarcoma is the most common type of bone cancer, especially in children and young adults. The primary treatment for osteosarcoma is a combination of surgery and chemotherapy, however prognoses remain poor due to chemoresistance and early metastases. Osteosarcoma stem cells appear to play central roles in tumor recurrence, metastases and chemoresistance via self-renewal and differentiation. Targeting these cells may provide a novel strategy in the treatment of osteosarcoma. This review summarizes current knowledge of this rare phenotype and recent advances in understanding the functions OSCs (osteosarcoma stem cells) in osteosarcoma, with the aim of improving therapies in the future. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
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