期刊
VACCINE
卷 38, 期 7, 页码 1723-1729出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2019.12.043
关键词
Foot-and-mouth; Virus; Vaccine; Pig; Maternally-derived antibody; Efficacy; Field trial
资金
- APQA's National Animal Disease Research Project
To control foot-and-mouth disease (FMD) outbreaks that originated in Jincheon County in South Korea between 2014 and 2015, several commercial vaccines were studied for their efficacy and serological performance in the field. In this study, the efficacy of the O/SKR 7/10 vaccine was evaluated by challenge with the FMD virus (FMDV) O/Jincheon/SKR/2014 (O Jincheon), which has the same O/SEA/Mya-98 lineage as the O/SKR/7/10 strain that was isolated in 2010 in South Korea, in FMD-seronegative pigs. Full protection against the O Jincheon virus was demonstrated as early as 14 days postvaccination, which was explained by the strong serological relationship (r(1) value: >= 0.92) between the O Jincheon and O SKR 2010 viruses. However, in the field trial, no satisfactory serological elevations against FMDV were observed, even in the double-vaccinated groups. Therefore, it can be concluded that the O SKR 7/10 vaccine may need to be improved to overcome the interference effects from the high levels of maternally-derived antibodies generated due to the mandatory nationwide vaccination of sows in South Korea. (C) 2019 Elsevier Ltd. All rights reserved.
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